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Review Article 08 March In this Review, new insights into the hypothalamic—pituitary—adrenal axis are integrated within a novel conceptual framework that can be used to re-appreciate adrenocortical function and dysfunction in the context of critical illness. Review Article 20 January Targeting the immune system in tumour sires has become a central therapy for cancer treatment, but such drugs can lead to adverse effects.

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In this Review, the authors describe the immune-related endocrinopathies, such as hypophysitis, thyroid dysfunction and the development of diabetes mellitus that can result from cancer immunotherapy. Review Article 17 June Patients with adrenoleukodystrophy have a complex, Sits peroxisomal disease, which is characterized by the development of adrenal insufficiency, myelopathy and progressive cerebral white matter lesions.

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The thyroid gland is a butterfly-shaped endocrine gland located in the neck underneath the cartilage tissue that forms the Adam's apple. Reviews 15 October Globally, the incidence of thyroid cancer is on the increase.

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This Review highlights the epidemiology of thyroid cancer in high-income, middle-income and low-income countries and discusses the prevalence of modifiable individual risk factors and population-level exposures to environmental risk factors.

Reviews 12 August Daily TSH secretion profiles are disrupted in some patients with hypothyroidism and hyperthyroidism.

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Dzting this Review, we consider the role of thyroglobulin in thyroid hormonogenesis from evolutionary, biochemical, molecular, cellular and physiological angles.]